Complications of type 2 diabetes, diminished. The combination that reduces the risk of cardiovascular and kidney diseases

A recent study looked at whether using two types of type 2 diabetes drugs, called GLP-1 receptor agonists and SGLT-2 inhibitors, together is better than using each one alone. The study looked at how this combination influences the risk of serious heart and kidney problems. The scientists used real data and a kind of experiment that resembled the one controlled by strict rules.

They created groups of people who started using one of the two types of drugs and compared those who also started using the other type with those who stayed on their original drug. They looked at things like serious heart and kidney problems, heart failure and death.

The bottom line? When used together, the two types of drugs reduced the risk of serious heart and kidney problems compared to using either alone. Adding one of the new drugs to existing treatment with the other type of drug also led to a lower risk of death from cardiovascular causes and heart failure.

So this combination may be better than each drug alone for people with type 2 diabetes. But more studies, including those that are closely controlled, are needed to be sure of these results and to see how they may used the two drugs to better help people with the condition, according to the study published in The BMJ.

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How the two drugs work

Diabetic person – PHOTO: Freepik@pikisuperstar

The study investigated how the combined use of two types of drugs, GLP-1 and SGLT-2, affected patients with type 2 diabetes. They wanted to see if this combination reduced the risk of heart and kidney problems compared to each drug used separately . They looked at data from UK patients and found that combining these drugs significantly reduced the risk of major heart and serious kidney problems.

The results suggest that using both drugs together may be more beneficial for these patients than using each drug alone.

A recent study aimed to determine whether the combination of GLP-1 receptor agonists and SGLT-2 inhibitors, commonly used to treat type 2 diabetes, reduces the risk of major cardiovascular and renal events compared to using each type of drug individually. . The study used real-life data and a design that emulates a randomized controlled trial.

The researchers created cohorts of new users of GLP-1 receptor agonists or SGLT-2 inhibitors and compared patients who added the other drug class to those who continued their original treatment. They looked at outcomes including major adverse cardiovascular events, serious renal events, heart failure and mortality.

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The combination of the two types of drugs reduces the risk of cardiovascular mortality and heart failure

The results showed that the combination of GLP-1 receptor agonists and SGLT-2 inhibitors was associated with a reduced risk of major adverse cardiovascular events and serious renal events compared with the use of each drug individually. Adding an SGLT-2 inhibitor to existing treatment with GLP-1 receptor agonists also reduced the risk of cardiovascular mortality and heart failure.

The study suggests that combining these two drug classes may provide additional benefits beyond monotherapy, possibly due to their distinct but complementary mechanisms of action. However, further research, including randomized controlled trials, is needed to confirm these findings and explore the full therapeutic potential of this combination for patients with type 2 diabetes.

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